In the end it was only going to take one goal to decide this game and unfortunately for us it went to the home side.
The dangerous Ross Hannah marked his last game on loan from Bradford City with his 10th goal of the season, sliding in to finish from close range.
The home side applied virtually all the early pressure through strikers Hannah and Andy Cook, with the Wrexham defence struggling to keep pace with the pair.
On 10 minutes, the home fans were screaming for a penalty as Craig Disley went to ground in the box, but the TV pictures agreed with referee Ross Joyce that Neil Ashton had won the ball without touching the Mariner.
A hamstring injury to manager Andy Morrell saw him replaced on 17 minutes by Ciss.
In terms of possession the game was then becoming more even as the half wore on and from a Dean Keates free kick, Martin Riley headed onto the roof of the home goal.
Shortly afterwards both Jay Harris and Ciss tried their luck from distance. The latter’s effort forcing keeper James McKeown into blocking the ball with his chest.
After the break, it was end to end stuff until the two on loan players combined for the winning strike with 13 minutes remaining.
To make matters worse, Ashton picked up a late booking for a foul on Marshall and will now serve a one-match ban on Boxing Day.
In the final few minutes, Joe Clarke and Nick Rushton were sent on and the former saw an effort from the edge of the box go just wide.
Grimsby Town: McKeown, Hatton, Miller, Pond, Thomas; Marshall, Niven, Disley, Neilson (Southwell 90); Hannah, Cook.
Subs: G Pearson, Wood, Thanoji, Rankine.
Wrexham: Mayebi, Devine, Riley, Westwood, Ashton; Hunt (Clarke 87), Keates, Harris; Ormerod (Rushton 87), Morrell (Cieslewicz 17), Wright.
Subs: Coughlin, Walker.
Referee: Ross Joyce (Cleveland)
Wrexham: Ashton (foul)