It was always going to be a tough night in south Wales, but one that was made much harder by the early dismissal of Luke Young for what was deemed a two-footed challenge after just 12 minutes.
Some of the radio contingent thought it was a harsh decision, but stills photographs seen later appeared to show the midfielder off the ground.
Whatever the rights or wrongs of the decision, it was a game changer and while the north Walians held out until the interval, it was a different story after the break - as Newport pushed home their advantage with four goals to kill the tie off.
The early exchanges were very much a continuation of the original tie at the Racecourse 10 days previously, with both sides battling hard and not giving an inch.
There was a straight red for Luke Young after he went for the ball with Mickey Demetriou on 12 minutes, the referee had no doubt the ex-Torquay man was off the floor and dismissed the midfielder.
There were also bookings for Shaun Pearson, Rob Lainton and Dan Butler in the aftermath.
County looked to press home their man advantage from the restart, as Wrexham adjusted to a new formation. On 20 minutes, they worked the overlapping winger well and a long range shot from Tyreeq Bakinson was week held by Rob Lainton.
As we approached the half hour, defenders Butler and Demetriou both had efforts that had the home crowd off their seats. Then an Antoine Semenyo cross from the left saw Jamille Matt dart in at the near post but put his effort wide from close range.
With five minutes remining of the first half, Paul Rutherford was quickly onto a loose ball 25-yards from the home goal, hit his effort early and force keeper Joe Day into a spectacular save, as the ball arrowed for the top corner of the net.
At the other end, Lainton was forced to grab a Matt header under his crossbar.
The half ended with five added minutes as the Reds were put under constant pressure by their opponents.
The Exiles took the lead four minutes in to the second half, after the Reds conceded a needless corner.
Dolan took the kick and delivered it deep to where Fraser Franks was unmarked and headed the ball towards striker Padraig Amond, but the ball actually came off the head of Mark Carringtonto to cross the line from close range.
Bennett was then replaced by Robbie Willmott on 51 minutes, in the first change of the evening.
There was a booking for the experienced David Pipe on 57 minutes, after he brought down Luke Summerfield – also a change for the visitors as Chris Holroyd come on for Beavon.
There was a second goal from County on 59 minutes, when the ball was kept in play on the left, crossed deep for Willmott to collect and pick out Jamille Matt, who slotted home a low shot into the bottom corner of Lainton’s net from a central position.
There was more disappointment on 65 minutes, when a quickly taken free kick was squared along the six-yard line and came off the heel of Carrington to fly into his own net for a third to Newport.
Before the restart, Jos Labadie came on for Dolan. And not long after Nicky Deverdics was introduced for Summerfield.
Prolonged treatment for Demetriou saw him taken off on 75 minutes and Cameron Pring took his place. Three minutes later and the final change of the evening was Mike Fondop on for Bobby Grant.
The Cameroonian earning a yellow card just two minutes later for a foul on the half way line.
While Willmott had some wayward finishing when well positioned, Lainton had to thank his woodwork for preventing a fourth on the final minute of normal time, as the winger unleased a vicious effort that cannoned back into play off a post.
Six added minutes were shown by the fourth official.
Not that a fourth was to be denied the home side for long, as full back Dan Butler unleased a long-range effort from out wide that gave Lainton no chance and bulged the back of the Wrexham net.
Yet at the final whistle the travelling Reds gave the players a great ovation, staying behind in numbers to clap the lads from the pitch.
Newport County: Day, Pipe, Butler, Franks, Dolan (Labdie 66), Amond, Matt, Bakinson, Bennett (Willmott 51), Demetriou (Pring 75), Semenyo.
Subs: Townsend, Harris, Sheehan, Forbes.
Wrexham: Lainton, Carrington, Lawlor, Pearson, Jennings, Wright, Summerfield (Deverdics 71), Young, Rutherford, Grant (Fondop 78), Beavon (Holroyd 57).
Subs: Dibble, Beaumont, Sargent, Thorn.
Referee: Kevin Johnson (Somerset)
Sending Off -
Wrexham: Young (Serious Foul Play 12)
Newport County: Butler (UGC 13), Pipe (foul 57)
Wrexham: Pearson (UGC 13), Lainton (UGC 13), Fondop (foul 81)