James Horsfield is in line for his debut, after his clearance was received in time for him to be eligible for today's Cup tie. Skipper Shaun Pearson is also in the line-up after suffering with a virus in midweek.
Seven substitutes are allowed in the FA Cup, so the bench sees both Mark Carrington and JJ Hooper return after injury.
Chesterfield: Jalal, Yarney, Sheridan, Evans, Hollis, Rowley, Weston, Nepomuceno, Fondop, Denton, Wedgbury.
Subs: Coddington, Mandeville, Smith, Gerrard, McGlashan, Boden, Spyrou.
Wrexham: Lainton, Horsfield, Lawlor, Pearson, Jennings, Summerfield, Barton, Young, Rutherford, Grant, Harris.
Subs: Dibble, Carrington, Wright, Redmond, Tollitt, Oswell, Hooper.
Referee: Peter Gibbons (Merseyside)