Kevin Roberts returns to the right back role after his three-match ban.
Leyton Orient: Brill, McAnuff, Bonne, Judd, Koroma, Ekpiteta, Clay, Happe, Brophy, Adams, Ling.
Subs: Grainger, Lee, Mooney, Clayden, Reynolds.
Wrexham: Dunn, Roberts, M Smith, Pearson, Jennings, Mackreth, Wedgbury, Kelly, Rutherford, Boden, Quigley.
Subs: Dibble, Raven, Wright, Deverdics, Ainge.
Referee: S Allison (Wiltshire)