A first start of the season for Christian Dibble in goal, while Nicky Deverdics is also in the line-up.
Luke Young starts a three-game suspension, while Kevin Roberts, Rekil Pyke, Doug Tharme, Jordan Maguire-Drew, Manny Smith and Shaun Pearson all miss out through injury or illness.
After being on the bench in midweek, both Matt Sargent and Jack Thorn are in the squad again today.
Wrexham: Dibble, Carrington, Lawlor, B Walker, Jennings, Summerfield, A Wright, Rutherford, Deverdics, Holroyd, Fondop.
Subs: Lainton, Sargent, Thorn, Beavon, Grant.
Boston United: Willis, Davies, Jackson, Thanoj, Harris, Qualter, M Wright, Abbott, Allott, Agnew, N Walker.
Subs: Malkowski, Gibbens, Wafula, Rollins, Slew.
Referee: Simon Mather