Luke Coddington rejoins the club on loan and makes his second debut, while James Jenings is back from suspension and Chris Holroyd starts after his shoulder injury.
Wrexham: Coddington, Roberts, M Smith, Pearson, Jennings, Rutrherford, Carrington, Wedgbury, Kelly, Holroyd, Boden.
Subs: Preston, Mackreth, Wright, Massanka, Reid.
Guiseley: Green, Brown, Lowe, Palmer, Lawlor, Hatfield, Rooney, Molyneux, Correia, Odejayi, Atkinson
Subs: Hurst, Thompson, Mulhern, Williams, East.
Referee: J Hull (Manchester)